First things first, your style is definitely not generic. Maria's unique style really drew me first - I like her attitude and her mix of feminine and masculine qualities. She's thin and leggy, but her bust isn't bigger than her head. She's a big gangly looking because of the sharp angles of her elbows, which is going to be tough to make look
right most of the time, because it's so anatomically aberrant, but here I think it works really nicely with your style.
Now for the constructive criticism. The lumps, in my opinion, need to go. As someone mentioned, they look like tumors. I mean the ones near elbows and calves. The ones on Nakeisha's calves are the most obvious. I understand you're trying to be stylistic ... many artists draw calves the size of quadriceps, but the key to making them look vaguely natural is to make the calves smooth (check my example below).
Just as Maria immediately caught my eye, so did Chloe, but in a different way entirely. While Maria is an incredibly cool character design, Chloe, in all honesty, looks kinda like a monkey. Sorry ... but her chin is just so non existent and her hands are huge and she doesn't have any hips to speak of. Plus her smile looks like a slit across her face. Anyway, I tweaked her face a bit so you could see what I mean ... I admit I made her slightly more generic and a little less tomboyish and more cute, but she's less simplified that way. I think she maintains most of her tomboyishness because her shoulders are so broad and square. I'm also not partial to her accordion legs. My edit's not the greatest, but it just shows that the crinkle of her pants around her legs should be a bit more varied.
As for Nakeisha, I altered her face slightly because she had no temples and her cheeks were slightly too large. I say go crazy with her eyelashes because she strikes me as someone who could wear a lot of makeup but still avoid tackiness. I also made her less crooked
If there's one tip I could give, it would be to avoid making things too stylistic. Maria works because you've nailed a mixture of cartoony vs realistic. Oh, and also, calves look bigger when they're viewed from the side than from the front (which is applicable to how you've drawn Maria's legs - that is, you've made her right calf the same thickness as her left calf, but her right calf should in fact be thinner than her left because it is being viewed from the front, while her left is being viewed from the side). And forearms don't "bulge" on the top and the bottom - they tend to be flatter on one side ... but that's another stylistic point, I suppose. If you can make Popeye arms work for women, all the more power to you.
My edits:
http://img.photobucket.com/albums/v106/ ... _edit2.jpg
Circles around the areas I made edits:
http://img.photobucket.com/albums/v106/ ... t2_red.jpg
Best of luck on your comic!